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Discussion

1997; Springer Nature; Volume: 16; Issue: 2 Linguagem: Inglês

10.1016/s0893-133x(96)00189-3

1740-634X

Bryan L. Roth, David Sibley,

In their manuscript, Seeman and colleagues propose that atypical antipsychotic drugs may be distinguished from typical antipsychotic drugs by either their low affinity for 0 2 dopamine receptors or their selectivity for 0 4 dopamine receptors.The idea that atypical antipsychotic drugs have a relatively low affinity for 0 2 dopamine receptors is a now widely accepted view since others (Meltzer et al. 1989;Roth et al. 1995) have previously reported that atypical antipsychotic drugs as a group tend to have significantly lower affinities for 0 2 dopamine receptors than typical antipsychotic drugs.Some of the other conclusions that Seeman and colleagues arrive at are not uniformly held, however.This commentary focuses on the second conclusion of Seeman and colleagues; namely, that some atypical antipsychotic drugs are selective for 0 4 dopamine receptors.In arriving at this conclusion, Seeman and colleagues cite an earlier work (Roth et al. 1995) and state that "perlapine, olanzapine, and clozapine are (found to be) selective for the dopamine 0 4 receptor, compared to the dopamine 0 2 receptor."Of the three compounds, only perlapine was actually selective with a D 2 : 0 4 ratio of 63, but olanzapine (0 2 :0 4 = 4.6) and clozapine (0 2 :0 4 = 5.3) can only be said to prefer 0 4 over 0 2 receptors.Using the numbers supplied in Table 1 by Seeman and colleagues, generally lower selectivity ratios are found with perlapine (2) olanzapine (l.85), and clozapine (28).One could argue