Portal de Periódicos da CAPES

Improvement in treatment abandonment in pediatric patients with cancer in Guatemala

2017; Wiley; Volume: 64; Issue: 10 Linguagem: Inglês

10.1002/pbc.26560

1545-5017

Elysia Alvarez, Midori Seppa, Silvia Rivas, Lucía Fuentes, Patricia Valverde, Federico Antillón‐Klussmann, Mauricio Castellanos, E. Alejandro Sweet‐Cordero, Kevin Messacar, John Kurap, Marisol Bustamante, Scott C. Howard, Bradley Efron, Sandra Luna‐Fineman,

Ethics and Legal Issues in Pediatric Healthcare

Treatment refusal and abandonment are major causes of treatment failure for children with cancer in low- and middle-income countries (LMICs), like Guatemala. This study identified risk factors for and described the intervention that decreased abandonment.This was a retrospective study of Guatemalan children (0-18 years) with cancer treated at the Unidad Nacional de Oncología Pediátrica (UNOP), 2001-2008, using the Pediatric Oncology Network Database. Treatment refusal was a failure to begin treatment and treatment abandonment was a lapse of 4 weeks or longer in treatment. The impact of medicina integral, a multidisciplinary psychosocial intervention team at UNOP was evaluated. Cox proportional hazards analysis identified the effect of demographic and clinical factors on abandonment. Kaplan-Meier analysis estimated the survival.Of 1,789 patients, 21% refused or abandoned treatment. Abandonment decreased from 27% in 2001 to 7% in 2008 following the implementation of medicina integral. Factors associated with increased risk of refusal and abandonment: greater distance to the centre (P < 0.001), younger age (P = 0.017) and earlier year of diagnosis (P < 0.001). Indigenous race/ethnicity (P = 0.002) was associated with increased risk of abandonment alone. Abandonment correlated with decreased overall survival: 0.57 ± 0.02 (survival ± standard error) for those who completed therapy versus 0.06 ± 0.02 for those who abandoned treatment (P < 0.001) at 8.3 years.This study identified distance, age, year of diagnosis and indigenous race/ethnicity as risk factors for abandonment. A multidisciplinary intervention reduced abandonment and can be replicated in other LMICs.