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The Midbody and its Remnant in Cell Polarization and Asymmetric Cell Division

2017; Springer Science+Business Media; Linguagem: Inglês

10.1007/978-3-319-53150-2_7

1861-0412

Christian Pohl,

Glycosylation and Glycoproteins Research

The midbody is a protein-dense assembly that forms during cytokinesis when the actomyosin ring constricts around bundling central spindle microtubules. After its initial description by Walther Flemming in the late nineteenth century and its rediscovery through electron microscopy in the 1960s and 1970s, its ultrastructural organization and the sequential recruitment of its molecular constituents has only been elucidated in the past decade. Recently, it has become clear that the midbody can serve as a polarity cue during asymmetric cell division, cell polarization, and spindle orientation by coordinating cytoskeletal organization, vesicular transport, and localized cortical cues. In this chapter, these newly emerging functions will be discussed as well as asymmetries during midbody formation and their consequences for cellular organization in tissues.