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Permeable Self-Assembled Molecular Containers for Catalyst Isolation Enabling Two-Step Cascade Reactions

2017; American Chemical Society; Volume: 139; Issue: 17 Linguagem: Inglês

10.1021/jacs.7b02745

1943-2984

Y. Ueda, Hiroaki Ito, Daishi Fujita, Makoto Fujita,

Asymmetric Hydrogenation and Catalysis

Establishment of a general one-pot cascade reaction protocol would dramatically reduce the effort of multistep organic synthesis. We demonstrate that the unique structure of M12L24 self-assembled complexes gives them the potential to serve as catalyst carriers for enabling continuous chemical transformations. A stereoselective cascade reaction (allylic oxidation followed by Diels–Alder cyclization) with two intrinsically incompatible catalysts was demonstrated. Our system is advantageous in terms of availability, scalability, and predictability.