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Influence of remote ischemic conditioning and tramadol hydrochloride on oxidative stress in kidney ischemia/reperfusion injury in rats

2017; Sociedade Brasileira Para o Desenvolvimento da Pesquisa em Cirurgia; Volume: 32; Issue: 3 Linguagem: Inglês

10.1590/s0102-865020170030000007

ISSN

1678-2674

Autores

Rita de Cássia Silva de Oliveira, Marcus Vinícius Henriques Brito, Rubens Fernando Gonçalves Ribeiro Júnior, Leonam Oliver Durval Oliveira, Andrew Moraes Monteiro, Fernando Mateus Viégas Brandão, Lainy Carollyne da Costa Cavalcante, Eduardo Henrique Herbster Gouveia, Higor Yuri Bezerra Henriques,

Tópico(s)

Anesthesia and Sedative Agents

Resumo

Purpose: To evaluate the effects of tramadol hydrochloride associated to remote ischemic perconditioning on oxidative stress.Methods: Twenty five male rats (Wistar) underwent right nephrectomy and were distributed into five groups: Sham group (S); Ischemia/Reperfusion group (I/R) with 30 minutes of renal ischemia; Remote ischemic perconditioning group (Per) with three cycles of 10 minutes of I/R performed during kidney ischemia; Tramadol group (T) treated with tramadol hydrochloride (40mg/kg); remote ischemic perconditioning + Tramadol group (Per+T) with both treatments.Oxidative stress was assessed after 24 hours of reperfusion.Results: Statistical differences were observed in MDA levels between I/R group with all groups (p<0.01), in addition there was difference between Tramadol with Sham, Per and Per+T groups (p<0.05),both in plasma and renal tissue.Conclusion: Remote ischemic perconditioning was more effective reducing renal ischemiareperfusion injury than administration of tramadol or association of both treatments.

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