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Effects of hydroalcoholic extract of Celtis iguanaea on markers of cardiovascular diseases and glucose metabolism in cholesterol-fed rats

2017; Springer Science+Business Media; Volume: 28; Issue: 1 Linguagem: Inglês

10.1016/j.bjp.2017.12.001

1981-528X

Barbara Zanchet, Denise B. Gomes, Vanessa da Silva Corralo, Kriptsan Abdon Poletto Diel, Amanda P. Schönell, Caroline Faust, Patrícia Avello Nicola, Liz Girardi Müller, Ana Paula Zanatta, Silvana M. Wildner, Fernanda Bevilaqua, Rafael Chitolina, Adrieli Sachett, Leïla Zanatta, Marta Maria Medeiros Frescura Duarte, Greicy M. M. Conterato, Cláudia Quintino da Rocha, Camile Peretti, Tatiane Brumelhaus, Nayara Souza Alves, Jean Carlo Olivo Menegatt, Fernanda Conte, Guilherme Serena, Adriano Tony Ramos, Francielli Cordeiro Zimermann, Walter Antônio Roman,

Pharmacological Effects of Natural Compounds

Celtis iguanaea (Jacq.) Sarg., Cannabaceae, is popularly used in the treatment of diabetes mellitus. However, chemical and pharmacological investigations are lacking. In this study, we investigated the effects of the hydroalcoholic extract from C. iguanaea on markers of cardiovascular diseases and the glucose metabolism in cholesterol-fed rats. Therefore, hypercholesterolemic rats (1% cholesterol) were orally treated with C. iguanaea extract (C-150, CI-300, or CI-600 mg/kg) or simvastatin (4 mg/kg) (n = 6) once a day (30 days) with a hypercholesterolemic diet. A control group (C) was given saline. C. iguanaea extract showed significant decreases in serum levels of total cholesterol, LDL-cholesterol, HMG-CoA-reductase, interleukin-1 and 6, TNF-α and IFN-γ when compared to group C (p < 0.001). Hypoglycemic effects were observed along with a decrease of the activity of sucrase (CI-600), maltase (CI-150, CI-300), and an increase in muscle glycogen levels (CI-300). Antioxidant effects were observed in plasma by the decrease of TBARS and increase of nonprotein thiols levels (CI-600). The histopathological analysis showed a significant decrease in the liver fat area for C. iguanaea extract compared to group C (p < 0.001). Our results suggest that the biological effects of C. iguanaea extract could be related to the flavonoids that possibly exert antioxidant, enzymatic inhibitory, and insulin-mimetic effects.