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Cellular Expression of PD-L1 in the Peripheral Blood of Lung Cancer Patients is Associated with Worse Survival

2017; American Association for Cancer Research; Volume: 26; Issue: 7 Linguagem: Inglês

10.1158/1055-9965.epi-17-0120

1538-7755

Daniel J. Boffa, Ryon P. Graf, Michelle C. Salazar, Jessica R. Hoag, David Lu, Rachel Krupa, Jessica Louw, Lyndsey Dugan, Yipeng Wang, Mark Landers, Mahipal Suraneni, Stephanie Greene, Marisa Magaña, Samir Makani, Lyudmila Bazhenova, Ryan Dittamore, Jorge J. Nieva,

Immune Cell Function and Interaction

Lung cancer treatment has become increasingly dependent upon invasive biopsies to profile tumors for personalized therapy. Recently, tumor expression of programmed death-ligand 1 (PD-L1) has gained interest as a potential predictor of response to immunotherapy. Circulating biomarkers present an opportunity for tumor profiling without the risks of invasive procedures. We characterized PD-L1 expression within populations of nucleated cells in the peripheral blood of lung cancer patients in hopes of expanding the role of liquid biopsy in this setting.