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1034 PREVALENCE AND FACTORS ASSOCIATED WITH SLEEP DISTURBANCE AND SLEEP APNEA AMONG PEOPLE LIVING WITH HIV

2017; Oxford University Press; Volume: 40; Issue: suppl_1 Linguagem: Inglês

10.1093/sleepj/zsx050.1033

1550-9109

Shu‐Wen Lin, Ching‐Kai Lin, Chi‐Sheng Hung, Kai‐Lun Yu, M. Shen, Yun Tang, W Liu, Pei‐Chi Wu, Shi‐Yi Yang, Yi Luo, J Zhang, Hao Chang, P Lee,

HIV/AIDS Research and Interventions

HIV infection had been reported to be associated with sleep disordered breathing (SDB) and insomnia in Westerns. No large-scale study had been conducted to investigate sleep disturbance in Asian people living with HIV (PLWH). We prospectively investigated the prevalence and predictors of sleep disturbance and obstructive sleep apnea (OSA) among PLWH in Taiwan, especially the role of depression. The consecutive HIV outpatients from 2 tertiary centers were recruited from date to date. The body composition, antiretroviral therapy usage, CD4 count, hypnotics/sedatives and illicit drugs usage, Beck depression inventory-II (BDI-II), Berlin Questionnaire, Epworth Sleepiness Scale (ESS), and Pittsburgh sleep quality index (PSQI) were collected. Body mass index (BMI)>24 kg/m2was considered as overweight. Poor sleep quality was defined as PSQI>5 and excessive daytime sleepiness (EDS) was defined as ESS>10 where depression was defined as BDI-II>16. Patients with high-risk Berlin questionnaire were considered as having OSA. Primary outcome was prevalence and predictors of poor sleep quality where secondary outcome was prevalence and predictors of OSA. A total of 484 consecutive HIV outpatients were recruited. 96.3% participants were men and 95.5% were under antiretroviral therapy. 78% participants had undetectable plasma viral load where the median CD4 count was 535.9 /mm3. 20% participants had OSA. Around 70% patients had poor sleep quality, 27% had EDS, and 26% had depression. Depression was the only independent factor predictive of poor sleep quality (OR: 3.22, 95% CI 1.89–5.50). Factors predictive of OSA included hypnotics/sedatives use (OR:1.75, 95% CI 1.05–2.93), BMI (kg/m2) (OR:1.13, 95% CI 1.06–1.21), depression (OR: 2.84, 95% CI 1.74–4.63) and antiretroviral agent with combination of integrase inhibitor (OR: 1.72, 95% CI 1.00–2.95). Viral load and CD4 count was not associated with any of poor sleep quality, OSA, and depression. The prevalence of sleep disturbance and OSA was high among Asian PLWH. Depression was predictive of both poor sleep quality and OSA. Moreover, hypnotics and antiretroviral agent were associated with OSA in addition to obesity. Ministry of science and technology (103-2314-B-002 -139 -MY3), NTUH 105-S2998, HCH104-069, ResMed Respiratory Medicine Institute Clinical study fund, NTU-NTUH-MediaTek Innovative Medical Electronics Research Center