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Maternal Inflammation, Fetal Brain Implications and Suggested Neuroprotection: A Summary of 10 Years of Research in Animal Models

2017; Rambam Health Care Campus; Volume: 8; Issue: 2 Linguagem: Inglês

10.5041/rmmj.10305

2076-9172

Yuval Ginsberg, Nizar Khatib, Zeev Weiner, Ron Beloosesky,

Pregnancy and preeclampsia studies

A growing body of evidence implies that maternal inflammation during pregnancy is associated with increased risk of neurodevelopmental disorders in the offspring.The pathophysiological mechanisms by which maternal inflammation evokes fetal brain injury and contributes to long-term adverse neurological outcomes are not completely understood.In this review, we summarize 10 years of our research experience on maternal inflammation and the implications upon the fetal/offspring brain.We review our findings regarding the underlying mechanisms that connects maternal inflammation and fetal brain injuries (e.g.cytokines, oxidative stress); we discuss our imaging, pathological and behavioral test results which support Maternal Inflammation and Fetal Brain Implicationsbrain damage following maternal inflammation; and finally we describe some of the therapeutic strategies which might prevent the damage.