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801. Developmental Nicotine Exposure Induces Persistent Alterations in Accumbens Glutamatergic Circuitry

2017; Elsevier BV; Volume: 81; Issue: 10 Linguagem: Inglês

10.1016/j.biopsych.2017.02.868

1873-2402

Cassandra D. Gipson, Gregory L. Powell, Armani P. Del Franco, H.M. Hanna Mike, Raul Garcia, Annika Vannan, Janet L. Neisewander,

Nicotinic Acetylcholine Receptors Study

Developmental nicotine exposure (DNE) is used to model human smoking during pregnancy, and has been shown to cause alterations in glutamate receptors, dendritic morphology, and neuronal function as well as increase nicotine (NIC) self-administration in adult rats. The underlying neurobiological mechanisms leading to increased nicotine addiction vulnerability following DNE, however, are unknown.