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The IASLC Lung Cancer Staging Project: External Validation of the Revision of the TNM Stage Groupings in the Eighth Edition of the TNM Classification of Lung Cancer

2017; Elsevier BV; Volume: 12; Issue: 7 Linguagem: Inglês

10.1016/j.jtho.2017.04.011

1556-1380

Kari Chansky, Frank Detterbeck, Andrew G. Nicholson, Valerie W. Rusch, Eric Vallières, Patti A. Groome, Catherine J. Kennedy, Mark Krasnik, Michael Peake, Lynn Shemanski, Vanessa Bolejack, John J. Crowley, Hisao Asamura, Ramón Rami–Porta, Peter Goldstraw, Ramón Rami–Porta, Hisao Asamura, David Ball, David G. Beer, R. Guijarro, Vanessa Bolejack, Kari Chansky, John Crowley, Frank Detterbeck, Wilfried Eberhardt, John Edwards, Françoise Galateau-Sallé, Dorothy J. Giroux, Fergus Gleeson, Patti A. Groome, James Huang, Catherine J. Kennedy, Young Tae Kim, Young Tae Kim, Laura Kingsbury, Haruhiko Kondo, Mark Krasnik, Kaoru Kubota, Antoon Lerut, Gustavo Lyons, Mirella Marino, Edith M. Marom, Jan P. van Meerbeeck, Alan Mitchell, Takashi Nakano, Andrew G. Nicholson, Anna K. Nowak, Michael Peake, Thomas W. Rice, Kenneth E. Rosenzweig, Enrico Ruffini, Valerie W. Rusch, Nagahiro Saijo, Paul Van Schil, Jean‐Paul Sculier, Lynn Shemanski, Kelly Stratton, Kenji Suzuki, Yuji Tachimori, Charles F. Thomas, William D. Travis, Ming‐Sound Tsao, Andrew T. Turrisi, Johan Vansteenkiste, Hirokazu Watanabe, Yi‐Long Wu, Paul Baas, Jeremy Erasmus, Seiki Hasegawa, Kouki Inai, Kemp Kernstine, Hedy L. Kindler, Lee M. Krug, Kristiaan Nackaerts, Harvey I. Pass, David C. Rice, Conrad Falkson, Pier Luigi Filosso, Giuseppe Giaccone, Kazuya Kondo, Marco Lucchi, Meinoshin Okumura, Eugene H. Blackstone, F. Abad Cavaco, Emilio Ansótegui Barrera, J. Abal Arca, Isaura Parente Lamelas, A. Arnau Obrer, R. Guijarro, David Ball, G.K. Bascom, Ana Isabel Blanco Orozco, M. A. González Castro, Matthew G. Blum, Domingo Chimondeguy, Vlado Cvijanović, Sebastián Defranchi, B. de Olaiz Navarro, I. Escobar Campuzano, Iván Macı́a, E. Fernández Araujo, F. Andreo García, Kwun M. Fong, Gloria Francisco Corral, S. Cerezo González, J. Freixinet Gilart, L. García Arangüena, S. García Barajas, Philippe Girard, Tuncay Göksel, M.T. González Budiño, Guillermo González Casaurrán, José Antonio Gullón Blanco, Jesús Hernández Hernández, H. Hernández Rodríguez, J. Herrero Collantes, M. Iglesias Heras, José Miguel Izquierdo Elena, Erik Jakobsen, S. Kostas, Pablo León Atance, Ana Núñez Ares, M. Liao, M. Losanovscky, Gustavo Lyons, R. Magaroles, L. De Esteban Júlvez, M. Mariñán Gorospe, Brian C. McCaughan, Catherine J. Kennedy, Rosario Melchor Íñiguez, Luis Miravet Sorribes, S. Naranjo Gozalo, C. Álvarez de Arriba, M. Núñez Delgado, J. Padilla Alarcón, Juan Carlos Peñalver Cuesta, James Park, Harvey I. Pass, M.J. Pavón Fernández, M Rosenberg, Enrico Ruffini, Valerie W. Rusch, Julio Sánchez de Cos Escuín, A. Saura Vinuesa, M. Serra Mitjans, Trond‐Eirik Strand, Dragan Subotic, Stephen G. Swisher, Ricardo Mingarini Terra, C. Thomas, Kurt G. Tournoy, Paul Van Schil, Mauricio Velásquez, Yi‐Long Wu, K. Yokoi,

Esophageal Cancer Research and Treatment

IntroductionRevisions to the TNM stage classifications for lung cancer, informed by the international database (N = 94,708) of the International Association for the Study of Lung Cancer (IASLC) Staging and Prognostic Factors Committee, need external validation. The objective was to externally validate the revisions by using the National Cancer Data Base (NCDB) of the American College of Surgeons.MethodsCases presenting from 2000 through 2012 were drawn from the NCDB and reclassified according to the eighth edition stage classification. Clinically and pathologically staged subsets of NSCLC were analyzed separately. The T, N, and overall TNM classifications were evaluated according to clinical, pathologic, and “best” stage (N = 780,294). Multivariate analyses were carried out to adjust for various confounding factors. A combined analysis of the NSCLC cases from both databases was performed to explore differences in overall survival prognosis between the two databases.ResultsThe databases differed in terms of key factors related to data source. Survival was greater in the IASLC database for all stage categories. However, the eighth edition TNM stage classification system demonstrated consistent ability to discriminate TNM categories and stage groups for clinical and pathologic stage.ConclusionsThe IASLC revisions made for the eighth edition of lung cancer staging are validated by this analysis of the NCDB database by the ordering, statistical differences, and homogeneity within stage groups and by the consistency within analyses of specific cohorts.