Control of DNA integrity in skeletal muscle under physiological and pathological conditions
2017; Springer Nature; Volume: 74; Issue: 19 Linguagem: Inglês
10.1007/s00018-017-2530-0
ISSN1420-9071
AutoresYara Bou Saada, Vlada Zakharova, Boris V. Chernyak, Carla Dib, Gilles Carnac, Svetlana Dokudovskaya, Yegor Vassetzky,
Tópico(s)Mitochondrial Function and Pathology
ResumoSkeletal muscle is a highly oxygen-consuming tissue that ensures body support and movement, as well as nutrient and temperature regulation. DNA damage induced by reactive oxygen species is present in muscles and tends to accumulate with age. Here, we present a summary of data obtained on DNA damage and its implication in muscle homeostasis, myogenic differentiation and neuromuscular disorders. Controlled and transient DNA damage appears to be essential for muscular homeostasis and differentiation while uncontrolled and chronic DNA damage negatively affects muscle health.
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