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Revisão Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Wnt/beta-catenin pathway: modulating anticancer immune response

2017; BioMed Central; Volume: 10; Issue: 1 Linguagem: Inglês

10.1186/s13045-017-0471-6

ISSN

1756-8722

Autores

Sachin Gopalkrishna Pai, Benedito A. Carneiro, José Maurício Mota, Ricardo Costa, Caio A. Leite, Romualdo Barroso‐Sousa, Jason Kaplan, Young Kwang Chae, Francis J. Giles,

Tópico(s)

Immunotherapy and Immune Responses

Resumo

Wnt/β-catenin signaling, a highly conserved pathway through evolution, regulates key cellular functions including proliferation, differentiation, migration, genetic stability, apoptosis, and stem cell renewal. The Wnt pathway mediates biological processes by a canonical or noncanonical pathway, depending on the involvement of β-catenin in signal transduction. β-catenin is a core component of the cadherin protein complex, whose stabilization is essential for the activation of Wnt/β-catenin signaling. As multiple aberrations in this pathway occur in numerous cancers, WNT-directed therapy represents an area of significant developmental therapeutics focus. The recently described role of Wnt/β-catenin pathway in regulating immune cell infiltration of the tumor microenvironment renewed the interest, given its potential impact on responses to immunotherapy treatments. This article summarizes the role of Wnt/β-catenin pathway in cancer and ongoing therapeutic strategies involving this pathway.

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