Artigo Acesso aberto Revisado por pares

Pre/pro-B cells generate macrophage populations during homeostasis and inflammation

2017; National Academy of Sciences; Volume: 114; Issue: 20 Linguagem: Inglês

10.1073/pnas.1616417114

ISSN

1091-6490

Autores

Tatsiana Audzevich, Rachael Bashford-Rogers, Neil A. Mabbott, Dan Frampton, Tom C. Freeman, Alexandre J. Potocnik, Paul Kellam, Derek W. Gilroy,

Tópico(s)

Immune Response and Inflammation

Resumo

Significance In this report we provide evidence of a source of macrophage (Mφ) populations that are derived from unique biphenotypic early pro-B cells with non-rearranged B-cell receptors. These early precursors give rise to either tissue resident- or monocyte-derived Mφs during homeostasis and inflammatory responses, thereby demonstrating functional plasticity depending on the environmental cues in adult mice. We suggest that these findings significantly advance and expand our understanding of Mφ biology and hematopoiesis, the plasticity of hematopoietic precursors, and the heterogeneity of Mφ subsets.

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