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Association between serum resistin concentration and hypertension: A systematic review and meta-analysis

2017; Impact Journals LLC; Volume: 8; Issue: 25 Linguagem: Inglês

10.18632/oncotarget.17561

1949-2553

Yuxiang Zhang, Yixing Li, Lin Yu, Lei Zhou,

Regulation of Appetite and Obesity

// Yuxiang Zhang 2, 3, 4, * , Yixing Li 1, * , Lin Yu 1 and Lei Zhou 1 1 State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Animal Science and Technology, Guangxi University, Nanning, 530004, P.R. China 2 The Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA 3 Pharmacology Graduate Program, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA 4 Public Health Certificate Program, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA * These authors contributed equally to this work Correspondence to: Lei Zhou, email: zhoulei@gxu.edu.cn Keywords: resistin, hypertension, meta-analysis Received: March 12, 2017 Accepted: April 19, 2017 Published: May 02, 2017 ABSTRACT Objectives: Recent studies have suggested the involvement of adipokines in the pathogenesis of cardiovascular diseases, including hypertension. In this study, we evaluated the significance of serum resistin levels in hypertensive patients using a meta-analysis approach. Materials and Methods: Relevant articles were retrieved by searching the following databases: PubMed, Embase, Ovid Medline, ISI Web of Knowledge. The retrieved studies were subjected to a thorough screening procedure to identify case-control studies that contained the required data. Data were extracted from each study and analyzed by Stata software and Review Manager software. In total, 14 case-control studies, containing 718 hypertensive patients and 645 normotensive controls, were included in this study. The major result of the meta-analysis revealed a statistically significant association between serum resistin concentration and hypertension (SMD = 0.85, 95% CI: [0.15, 1.54]), and the association was more obvious in Asian and Hispanic populations, diabetic population and studies with larger size cohorts. Publication bias was a low probability event for overall comparisons. Conclusions: Based on our results, we conclude that serum resistin level in hypertensive patients is higher than normotensive controls, indicating resistin might be a risk factor for hypertension.