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New Acetylenic Acids and Derivatives from the Edible Mushroom Craterellus lutescens (Cantharellaceae)

2017; American Chemical Society; Volume: 65; Issue: 19 Linguagem: Inglês

10.1021/acs.jafc.7b00899

1520-5118

Ying Huang, Shuai‐Bing Zhang, He‐Ping Chen, Zhen‐Zhu Zhao, Zhong‐Yu Zhou, Zheng-Hui Li, Tao Feng, Ji‐Kai Liu,

Allelopathy and phytotoxic interactions

Thirteen new acetylenic acids and their derivatives, craterellynes G-Q (1, 2, 4-10, 12, 13), 9-epi-craterellyne H (3), and 14-O-ethyl-craterellyne O (11), were isolated from the fruiting bodies of edible mushrooms Craterellus lutescens. The structures of these compounds were identified by various spectroscopic and chemical means. The stereoconfigurations of 1-13 were elucidated by the combination of acetonide formation, J-based configuration analysis, and modified Mosher's method. Craterellyne I exhibited cytotoxicities against human cancer strains and inhibition of nitric oxide (NO) production, as well as weak antimicrobial activity against Candida albicans.