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BIBTEX RIS

Molecular mechanisms of glucose uptake in skeletal muscle at rest and in response to exercise

2017; UNIVERSIDADE EST.PAULISTA JÚLIO DE MESQUITA FILHO; Volume: 23; Issue: spe Linguagem: Inglês

10.1590/s1980-6574201700si0004

ISSN

1980-6574

Autores

Rodrigo Martins Pereira, Leandro Pereira de Moura, Vitor Rosetto Muñoz, Adelino Sánchez Ramos da Silva, Rodrigo S. Gaspar, Eduardo R. Ropelle, José Rodrigo Pauli,

Tópico(s)

Pancreatic function and diabetes

Resumo

Glucose uptake is an important phenomenon for cell homeostasis and for organism health. Under resting conditions, skeletal muscle is dependent on insulin to promote glucose uptake.Insulin, after binding to its membrane receptor, triggers a cascade of intracellular reactions culminating in activation of the glucose transporter 4, GLUT4, among other outcomes.This transporter migrates to the plasma membrane and assists in glucose internalization.However, under special conditions such as physical exercise, alterations in the levels of intracellular molecules such as ATP and calcium actto regulate GLUT4 translocation and glucose uptake in skeletal muscle, regardless of insulinlevels.Regular physical exercise, due to stimulating pathways related to glucose uptake, is an important non-pharmacological intervention for improving glycemic control in obese and diabetic patients. In this mini-review the main mechanisms involved in glucose uptake in skeletal muscle in response to muscle contraction will be investigated.

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