Acoustic radiation force impulse imaging for detection of liver fibrosis in overweight and obese children
2017; SAGE Publishing; Volume: 59; Issue: 2 Linguagem: Inglês
10.1177/0284185117707359
ISSN1600-0455
AutoresJuan D. Berná-Serna, Regina Sánchez-Jiménez, Francisca Velázquez-Marín, Pilar Sáinz de Baranda, Florentina Guzmán‐Aroca, Carmen Fernández-Hernández, Ernesto Doménech‐Abellán, Dolores Abellán-Rivero, Guadalupe Ruíz-Merino, Juan Madrid-Conesa, Manuel Canteras-Jordana,
Tópico(s)Liver Diseases and Immunity
ResumoBackground Acoustic radiation force impulse (ARFI) is a non-invasive alternative to a liver biopsy for the evaluation of liver fibrosis (LF). Purpose To investigate the potential usefulness of acoustic radiation force impulse ARFI for detecting LF in overweight and obese children Material and Methods A cross-sectional study was conducted in 148 schoolchildren. A diagnosis of non-alcoholic fatty liver disease (NAFLD) and LF was based on ultrasound (US) and ARFI shear wave velocity (SWV). Results The laboratory parameters were normal in all the children. NAFLD was observed in 50 children (33.8%). The median SWV was 1.18 ± 0.28 m/s. Differences between ARFI categories and hepatic steatosis grades were observed (χ2 = 43.38, P = 0.0005). No fibrosis or insignificant fibrosis (SWV ≤ 1.60 m/s) was detected in 137 children (92.5%), and significant fibrosis (SWV > 1.60 m/s) in 11 children (7.5%), nine of whom had normal US or mild steatosis. Conclusion The present study is the first to evaluate the utility of the ARFI technique for detecting LF in overweight and obese children. The results of the study suggest that children with normal laboratory parameters such as normal liver ultrasound or mild steatosis may present with significant LF.
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