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Pericytes are heterogeneous in their origin within the same tissue

2017; Elsevier BV; Volume: 427; Issue: 1 Linguagem: Inglês

10.1016/j.ydbio.2017.05.001

1095-564X

Pedro H. D. M. Prazeres, Isadora F. G. Sena, Isabella da Terra Borges, Patrick O. Azevedo, Julia P. Andreotti, Ana Paiva, Viviani Mendes de Almeida, Daniel Arthur de Paula Guerra, Gabryella S. P. Santos, Akiva Mintz, Osvaldo Delbono, Alexander Birbrair,

Hippo pathway signaling and YAP/TAZ

Pericytes heterogeneity is based on their morphology, distribution, and markers. It is well known that pericytes from different organs may have distinct embryonic sources. Yamazaki et al. (2017) using several transgenic mouse model reveal by cell-lineage tracing that pericytes are even more heterogeneous than previously appreciated. This study shows that pericytes from within the same tissue may be heterogeneous in their origin. Remarkably, a subpopulation of embryonic dermal pericytes derives from the hematopoietic lineage, an unexpected source. Reconstructing the lineage of pericytes is central to understanding development, and also for the diagnosis and treatment of diseases in which pericytes play important roles.