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Genome-wide association study identifies multiple risk loci for renal cell carcinoma

2017; Nature Portfolio; Volume: 8; Issue: 1 Linguagem: Inglês

10.1038/ncomms15724

2041-1723

Ghislaine Scélo, Mark P. Purdue, Kevin M. Brown, Mattias Johansson, Zhaoming Wang, Jeanette E. Eckel‐Passow, Yuanqing Ye, Jonathan N. Hofmann, Jiyeon Choi, Matthieu Foll, Valérie Gaborieau, Mitchell J. Machiela, Leandro M. Colli, Peng Li, Joshua N. Sampson, Behnoush Abedi‐Ardekani, Céline Besse, Hélène Blanché, Anne Boland, Laurie Burdette, Amélie Chabrier, Geoffroy Durand, Florence Le Calvez‐Kelm, Egor Prokhortchouk, Nivonirina Robinot, K. G. Skryabin, Magdalena B. Wozniak, Meredith Yeager, Gordana Basta-Jovanović, Zoran Džamić, Lenka Foretová, Ivana Holcátová, Vladimí­r Janout, Dana Mateș, Anush Mukeriya, Ștefan Rașcu, Давид Заридзе, Vladimír Bencko, Cezary Cybulski, Eleonóra Fabiánová, Viorel Jinga, Jolanta Lissowska, Jan Lubiński, Marie Navratilova, Péter Rudnai, Neonila Szeszenia‐Dąbrowska, Simone Benhamou, Géraldine Cancel‐Tassin, Olivier Cussenot, Laura Baglietto, Heiner Boeing, Kay‐Tee Khaw, Elisabete Weiderpass, Börje Ljungberg, Raviprakash T. Sitaram, Fiona Bruinsma, Susan J. Jordan, Gianluca Severi, Ingrid Winship, Kristian Hveem, Lars J. Vatten, Tony Fletcher, Kvetoslava Koppová, Susanna C. Larsson, Alicja Wolk, Rosamonde E. Banks, Peter J. Selby, Douglas F. Easton, Paul D.P. Pharoah, Gabriella Andreotti, Laura E. Beane Freeman, Stella Koutros, Demetrius Albanes, Satu Männistö, Stephanie J. Weinstein, Peter E. Clark, Todd L. Edwards, Loren Lipworth, Susan M. Gapstur, Victoria L. Stevens, Hallie Carol, Matthew L. Freedman, Mark M. Pomerantz, Eunyoung Cho, Peter Kraft, Mark A. Preston, Kathryn M. Wilson, J. Michael Gaziano, Howard D. Sesso, Amanda Black, Neal D. Freedman, Wen‐Yi Huang, John Anema, Richard J. Kahnoski, Brian R. Lane, Sabrina L. Noyes, David Petillo, Bin Tean Teh, Ulrike Peters, Emily White, Garnet L. Anderson, Lisa Johnson, Juhua Luo, Julie E. Buring, I‐Min Lee, Wong‐Ho Chow, Lee E. Moore, Christopher G. Wood, Timothy Eisen, Marc Henrion, James Larkin, Poulami Barman, Bradley C. Leibovich, Toni K. Choueiri, G.M. Lathrop, Nathaniel Rothman, Jean‐François Deleuze, James McKay, Alexander S. Parker, Xifeng Wu, Richard S. Houlston, Paul Brennan, Stephen J. Chanock,

Renal cell carcinoma treatment

Abstract Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P =3.1 × 10 −10 ), 3p22.1 (rs67311347, P =2.5 × 10 −8 ), 3q26.2 (rs10936602, P =8.8 × 10 −9 ), 8p21.3 (rs2241261, P =5.8 × 10 −9 ), 10q24.33-q25.1 (rs11813268, P =3.9 × 10 −8 ), 11q22.3 (rs74911261, P =2.1 × 10 −10 ) and 14q24.2 (rs4903064, P =2.2 × 10 −24 ). Expression quantitative trait analyses suggest plausible candidate genes at these regions that may contribute to RCC susceptibility.