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Tumor-infiltrating FoxP3+ Tregs predict favorable outcome in colorectal cancer patients: A meta-analysis

2017; Impact Journals LLC; Volume: 8; Issue: 43 Linguagem: Inglês

10.18632/oncotarget.17722

1949-2553

Guoming Hu, Zhian Li, Shimin Wang,

Colorectal Cancer Treatments and Studies

// Guoming Hu 1 , Zhi'an Li 2 and Shimin Wang 3 1 Department of General Surgery (Breast and Thyroid Surgery), Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, 312000, Shaoxing, China 2 Department of Surgical Oncology, Shaoxing Second Hospital, 312000, Shaoxing, China 3 Department of Nephrology, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, 312000, Shaoxing, China Correspondence to: Guoming Hu, email: hgmplj@126.com Shimin Wang, email: wangsm0@163.com Keywords: tumor-infiltrating FoxP3 + Tregs, favorable outcome, human colorectal cancer, meta-analysis Received: December 22, 2016 Accepted: April 11, 2017 Published: June 07, 2017 ABSTRACT FoxP3 + regulatory T cells (FoxP3 + Tregs) are considered to be a key mediator in immune escape and tumor progression. However, the role of FoxP3 + Tregs in human colorectal cancer (CRC) remains controversial. Herein, we conducted a meta-analysis including 17 published studies with 3811 patients identified from PubMed and EBSCO to assess the prognostic impact of tumor-infiltrating FoxP3 + Tregs in human CRC. We found FoxP3 + Tregs infiltrating into both intraepithelium and stroma within tumor were significantly positively correlated with 1, 3, 5 and 10-year overall survival (OS), but not with 1, 3, 5-year disease-free survival (DFS) of patients. Interestingly, in stratified analyses by compartments within tumor FoxP3 + Tregs infiltrating into, FoxP3 + Tregs invading stromal compartment significantly improved 3 and 5-year OS, yet OS wasn't improved when FoxP3 + Tregs infiltrated into intraepithelium only. Furthermore, FoxP3 + Tregs invading both intraepithelium and stroma significantly inversely correlated with TNM stage of CRC. In conclusion, High density of FoxP3 + Tregs within tumor especially at stromal compartment leads to a favorable outcome in CRC, implicating FoxP3 + Tregs are one of valuable indexes for prognostic prediction in human CRC.