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Artigo Acesso aberto Revisado por pares
BIBTEX RIS

Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly

2017; Elsevier BV; Volume: 130; Issue: 6 Linguagem: Inglês

10.1182/blood-2017-02-769869

ISSN

1528-0020

Autores

Florian Zink, Simon Stacey, Gudmundur L. Norddahl, Michael L. Frigge, Ólafur Þ. Magnússon, Ingileif Jónsdóttir, Thorgeir E. Thorgeirsson, Ásgeir Sigurðsson, Sigurjón A. Guðjónsson, Jūlı́us Guðmundsson, Jón G. Jónasson, Laufey Tryggvadóttír, Þorvaldur Jónsson, Agnar Helgason, Arnaldur Gylfason, Patrick Sulem, Þórunn Rafnar, Unnur Þorsteinsdóttir, Daníel F. Guðbjartsson, Gísli Másson, Augustine Kong, Kāri Stefánsson,

Tópico(s)

Cancer Genomics and Diagnostics

Resumo

Key Points Whole-genome sequencing of 11 262 Icelanders reveals that clonal hematopoiesis is very common in the elderly. Somatic mutation of some genes is strongly associated with clonal hematopoiesis, but in most cases, no driver mutations were evident.

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