Portal de Periódicos da CAPES

Mantle cell lymphoma: from pathology and molecular pathogenesis to new therapeutic perspectives.

2006; National Institutes of Health; Volume: 91; Issue: 1 Linguagem: Inglês

Itziar Salaverría, Patricia Pérez‐Galán, Dolors Colomer, Elı́as Campo,

Ubiquitin and proteasome pathways

Thislymphoma is composed of a monomorphic prolifera-tion of small to medium sized lymphoid cells with ir reg-ular nuclei of mature B-cell phenotype commonly co-expressing CD5. The correlations between these specif-ic pathological characteristics and the genetic andmolecular alterations have been crucial in defining thislymphoma and recognizing its broad morphologicaland clinical manifestations, which in turn have lead to abetter understanding of the molecular mechanismsunderlying the development and progression of the dis-ease. The clinical behavior is very aggressive and fewpatients reach long survival with current therapeuticprotocols and even fewer may be considered cured. Thebetter knowledge of this disease, the development ofnew preclinical models, and the emergence of a newgeneration of drugs are facilitating the design of newtherapeutic strategies that may overcome the resistanceof this aggressive lymphoma to conventional treatmentsand may improve the life expectancy of the patients.