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Predictors of glycemic control in the first year of diagnosis of childhood onset type 1 diabetes: A systematic review of quantitative evidence

2017; Wiley; Volume: 19; Issue: 1 Linguagem: Inglês

10.1111/pedi.12530

1399-5448

Veena Mazarello Paes, Dimitrios Charalampopoulos, Julie Edge, David Taylor‐Robinson, Terence Stephenson, Rakesh Amin,

Diabetes and associated disorders

Pediatric DiabetesVolume 19, Issue 1 p. 18-26 REVIEW ARTICLE Predictors of glycemic control in the first year of diagnosis of childhood onset type 1 diabetes: A systematic review of quantitative evidence Veena Mazarello Paes, Corresponding Author Veena Mazarello Paes veena.paes.14@ucl.ac.uk orcid.org/0000-0002-4283-6266 Children's Policy Research Unit, Great Ormond Street Institute of Child Health, University College London, London, UK Department of Paediatrics, University of Cambridge, Cambridge, UKCorrespondence Veena Mazarello Paes, Great Ormond Street Institute of Child Health, University College London, 1st floor, Wellcome Trust Building, 30 Guilford Street, London WC1N 1EH, UK. Email: veena.paes.14@ucl.ac.ukSearch for more papers by this authorDimitrios Charalampopoulos, Dimitrios Charalampopoulos Children's Policy Research Unit, Great Ormond Street Institute of Child Health, University College London, London, UKSearch for more papers by this authorJulie Edge, Julie Edge Department of Paediatric Endocrinology and Diabetes, University of Oxford, Oxford, UKSearch for more papers by this authorDavid Taylor-Robinson, David Taylor-Robinson Children's Policy Research Unit, Great Ormond Street Institute of Child Health, University College London, London, UK Department of Public Health and Policy, University of Liverpool, Liverpool, UKSearch for more papers by this authorTerence Stephenson, Terence Stephenson Children's Policy Research Unit, Great Ormond Street Institute of Child Health, University College London, London, UKSearch for more papers by this authorRakesh Amin, Rakesh Amin Children's Policy Research Unit, Great Ormond Street Institute of Child Health, University College London, London, UKSearch for more papers by this author Veena Mazarello Paes, Corresponding Author Veena Mazarello Paes veena.paes.14@ucl.ac.uk orcid.org/0000-0002-4283-6266 Children's Policy Research Unit, Great Ormond Street Institute of Child Health, University College London, London, UK Department of Paediatrics, University of Cambridge, Cambridge, UKCorrespondence Veena Mazarello Paes, Great Ormond Street Institute of Child Health, University College London, 1st floor, Wellcome Trust Building, 30 Guilford Street, London WC1N 1EH, UK. Email: veena.paes.14@ucl.ac.ukSearch for more papers by this authorDimitrios Charalampopoulos, Dimitrios Charalampopoulos Children's Policy Research Unit, Great Ormond Street Institute of Child Health, University College London, London, UKSearch for more papers by this authorJulie Edge, Julie Edge Department of Paediatric Endocrinology and Diabetes, University of Oxford, Oxford, UKSearch for more papers by this authorDavid Taylor-Robinson, David Taylor-Robinson Children's Policy Research Unit, Great Ormond Street Institute of Child Health, University College London, London, UK Department of Public Health and Policy, University of Liverpool, Liverpool, UKSearch for more papers by this authorTerence Stephenson, Terence Stephenson Children's Policy Research Unit, Great Ormond Street Institute of Child Health, University College London, London, UKSearch for more papers by this authorRakesh Amin, Rakesh Amin Children's Policy Research Unit, Great Ormond Street Institute of Child Health, University College London, London, UKSearch for more papers by this author First published: 10 May 2017 https://doi.org/10.1111/pedi.12530Citations: 10 Department of Health, UK and the National Institute for Health Research Biomedical Research Centre at Great Ormond Street Hospital for Children NHS Foundation Trust and University College London Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Early glycemic control is associated with reduced future vascular complications risk in type 1 diabetes (T1D). The aim of this study was to systematically review evidence on the predictors of glycemic control within 12 months of diagnosis of childhood onset T1D. Inclusion criteria for the electronic search were: interventional and observational studies that assessed and quantified an association between the predictor and glycemic control within 12 months of diagnosis of childhood onset T1D. A total of 17 915 articles were identified from 6 databases and 20 studies were finally included in the analysis. Harvest plots and narrative synthesis were used to summarize data from intervention (n = 0), prospective/retrospective cohort (n = 15), and cross-sectional (n = 5) studies. Significant predictors of poorer glycemic control 0 to 3 months after diagnosis were older age and female gender. Non-white ethnicity, diabetes autoantibody positivity, measures of deprivation, and non-private health insurance were potential predictors. Predictors of poorer glycemic control 4 to 12 months after diagnosis were: older age, non-white ethnicity, a single parent family, high hemoglobin A1c (HbA1c) levels at diagnosis, longer T1D duration, and non-intensive insulin therapy. Potential predictors included: family with health issues, clinical factors, and comorbidities at diagnosis. Most significant predictors of poor glycemic control within 12 months of diagnosis of childhood onset T1D are non-modifiable. These factors need to be recognized and addressed through individualized and multidisciplinary diabetes care. Further research is required to confirm the association of potential predictors with early glycemic control. Citing Literature Supporting Information Filename Description pedi12530-sup-0001-AppendixS1.pdfPDF document, 760.4 KB TABLE S1. Electronic database search strategy TABLE S2. Inclusion and exclusion criteria for review of evidence on what factors predict early hemoglobin A1c (HbA1c)? TABLE S3. Quality assessment criteria TABLE S4. Details of data extracted from included studies TABLE S5. Predictors of early glycemic control in childhood onset type 1 diabetes (T1D): evidence from longitudinal studies TABLE S6. Correlates of early glycemic control in childhood onset type 1 diabetes (T1D): evidence from cross-sectional studies Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume19, Issue1February 2018Pages 18-26 RelatedInformation