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Body mass index and breast cancer survival: a Mendelian randomization analysis

2017; Oxford University Press; Volume: 46; Issue: 6 Linguagem: Inglês

10.1093/ije/dyx131

1464-3685

Qi Guo, Stephen Burgess, Constance Turman, Manjeet K. Bolla, Qin Wang, Michael Lush, Jean Abraham, Kristiina Aittomäki, Irene L. Andrulis, Carmel Apicella, Volker Arndt, Myrto Barrdahl, Javier Benı́tez, Christine D. Berg, Carl Blomqvist, Stig E. Bojesen, Bernardo Bonanni, Judith S. Brand, Hermann Brenner, Annegien Broeks, Barbara Burwinkel, Carlos Caldas, Daniele Campa, Federico Canzian, Jenny Chang‐Claude, Stephen J. Chanock, Suet‐Feung Chin, Fergus J. Couch, Angela Cox, Simon S. Cross, Cezary Cybulski, Kamila Czene, Hatef Darabi, Peter Devilee, W. Ryan Diver, Alison M. Dunning, Helena Earl, Diana Eccles, Arif B. Ekici, Mikael Eriksson, D. Gareth Evans, Peter A. Fasching, Jonine D. Figueroa, Dieter Flesch‐Janys, Henrik Flyger, Susan M. Gapstur, Mia M. Gaudet, Graham G. Giles, Gord Glendon, Mervi Grip, Jacek Gronwald, Lothar Haeberle, Christopher A. Haiman, Per Hall, Ute Hamann, Susan E. Hankinson, Jaana M. Hartikainen, Alexander Hein, Louise Hiller, Frans B.L. Hogervorst, Bernd Holleczek, Maartje J. Hooning, Robert N. Hoover, Keith Humphreys, David J. Hunter, Anika Hüsing, Anna Jakubowska, Arja Jukkola‐Vuorinen, Rudolf Kaaks, Maria Kabisch, Vesa Kataja, Julia A. Knight, Linetta B. Koppert, Veli‐Matti Kosma, Vessela N. Kristensen, Diether Lambrechts, Loı̈c Le Marchand, Jingmei Li, Annika Lindblom, Sara Lindström, Jolanta Lissowska, Jan Lubiński, Mitchell J. Machiela, Graham J. Mann, Siranoush Manoukian, Sara Margolin, F. Marmé, John W.M. Martens, Catriona McLean, Primitiva Menéndez, Roger L. Milne, Anna Marie Mulligan, Taru Muranen, Heli Nevanlinna, Patrick Neven, Sune F. Nielsen, Børge G. Nordestgaard, Janet E. Olson, Jose IA Perez, Paolo Peterlongo, Kelly‐Anne Phillips, Christopher Poole, Katri Pylkäs, Paolo Radice, Nazneen Rahman, Thomas Rüdiger, Anja Rudolph, Elinor J. Sawyer, Fredrick R. Schumacher, Petra Seibold, Caroline Seynaeve, Mitul Shah, Ann Smeets, Melissa C. Southey, Rob A.�E.�M. Tollenaar, Ian Tomlinson, Helen Tsimiklis, Hans-Ulrich Ulmer, Celine M. Vachon, Ans MW van den Ouweland, Laura J. van’t Veer, Hans Wildiers, Walter C. Willett, Robert Winqvist, M. Pilar Zamora, Georgia Chenevix‐Trench, Thilo Dörk, Douglas F. Easton, Montserrat García‐Closas, Peter Kraft, John L. Hopper, Wei Zheng, Marjanka K. Schmidt, Paul D.P. Pharoah,

Genetic factors in colorectal cancer

There is increasing evidence that elevated body mass index (BMI) is associated with reduced survival for women with breast cancer. However, the underlying reasons remain unclear. We conducted a Mendelian randomization analysis to investigate a possible causal role of BMI in survival from breast cancer.