SMYD2-Mediated Histone Methylation Contributes to HIV-1 Latency
2017; Cell Press; Volume: 21; Issue: 5 Linguagem: Inglês
10.1016/j.chom.2017.04.011
ISSN1934-6069
AutoresDaniela Boehm, Mark Y. Jeng, Grégory Camus, Andrea Gramatica, Roland Schwarzer, Jeffrey R. Johnson, Philip A. Hull, Mauricio Montaño, Naoki Sakane, Sara Pagans, Robert Godin, Steven G. Deeks, Nevan J. Krogan, Warner C. Greene, Mélanie Ott,
Tópico(s)Epigenetics and DNA Methylation
ResumoTranscriptional latency of HIV is a last barrier to viral eradication. Chromatin-remodeling complexes and post-translational histone modifications likely play key roles in HIV-1 reactivation, but the underlying mechanisms are incompletely understood. We performed an RNAi-based screen of human lysine methyltransferases and identified the SET and MYND domain-containing protein 2 (SMYD2) as an enzyme that regulates HIV-1 latency. Knockdown of SMYD2 or its pharmacological inhibition reactivated latent HIV-1 in T cell lines and in primary CD4
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