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Enhancement of Glucuronide-Conjugating Capacity in a Hyperbilirubinemic Infant Due to Apparent Enzyme Induction by Phenobarbital

1966; Massachusetts Medical Society; Volume: 275; Issue: 26 Linguagem: Inglês

10.1056/nejm196612292752602

1533-4406

Sumner J. Yaffe, Gerhard Levy, Tai Matsuzawa, Tadla Baliah,

Methemoglobinemia and Tumor Lysis Syndrome

GLUCURONIDE conjugation is an important mechanism for the elimination of endogenous and exogenous substances from the human body.1 A defect in this mechanism leads to increased concentrations of unconjugated bilirubin in the blood, and the latter is therefore frequently a reflection of impaired glucuronide synthesis.2 Patients with unusually low capacity for the conjugation of bilirubin show a similar reduced capacity for glucuronide conjugation of certain drugs that are ordinarily metabolized and eliminated by that process.3 , 4 Congenital, nonobstructive, nonhemolytic jaundice, which is thought to be due to a functional impairment of the glucuronyl transferase system, presents a particularly serious and difficult . . .