Portal de Periódicos da CAPES

Platelets in inflammation and atherogenesis

2005; American Society for Clinical Investigation; Volume: 115; Issue: 12 Linguagem: Inglês

10.1172/jci27196

1558-8238

Meinrad Gawaz,

Inflammatory Biomarkers in Disease Prognosis

Platelets represent an important linkage between inflammation, thrombosis, and atherogenesis. Inflammation is characterized by interactions among platelets, leukocytes, and ECs. These interactions trigger autocrine and paracrine activation processes that lead to leukocyte recruitment into the vascular wall. Platelet-induced chronic inflammatory processes at the vascular wall result in development of atherosclerotic lesions and atherothrombosis. This Review highlights the molecular machinery and inflammatory pathways used by platelets to initiate and accelerate atherothrombosis.