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2‐, 3‐ and 4‐[ 18 F]Fluoropyridine by no‐carrier‐added nucleophilic aromatic substitution with K[ 18 F]F‐K 222 – a comparative study

2003; Wiley; Volume: 46; Issue: 10 Linguagem: Inglês

10.1002/jlcr.730

1099-1344

Mylène Karramkam, Françoise Hinnen, F. Vaufrey, F. Dollé,

DNA and Nucleic Acid Chemistry

Abstract Compared to homoaromatic and aliphatic nucleophilic radiofluorinations, only few references can be found in the literature describing nucleophilic substitutions with [ 18 F]fluoride ion of heteroaromatic compounds such as pyridines and only reactions involving fluorination processes at the ortho ‐position (2‐position) have been more intensively studied. In the present paper, the scope of the nucleophilic aromatic fluorinations at the meta ‐ and para ‐position of the pyridine ring with no‐carrier‐added [ 18 F]fluoride ion as its activated K[ 18 F]F‐K 222 complex has been evaluated and compared to the nucleophilic aromatic fluorinations at the ortho ‐position in this pyridine series. The syntheses of 3‐ and 4‐[ 18 F]fluoropyridines were chosen as model reactions and compared to the radiosynthesis of 2‐[ 18 F]fluoropyridine. The parameters studied include the influence of the position of the leaving group at the pyridine ring, as well as the quantity of the precursor used, the type of activation (conventional heating, microwave irradiation), the solvent, the temperature and the reaction time. Using the corresponding nitro precursor, high yields were obtained at the 2‐position (94% yield) using microwaves (100 W) for 2 min in DMSO. Good yields (up to 72%) were observed at the 4‐position using the same conditions while practically no reaction was observed at the 3‐position. About 60% yield was also obtained at both the 2‐ and 4‐position using the corresponding nitro precursor at 145°C for 10 min in DMSO. Copyright © 2003 John Wiley & Sons, Ltd.