ATP as a biological hydrotrope
2017; American Association for the Advancement of Science; Volume: 356; Issue: 6339 Linguagem: Inglês
10.1126/science.aaf6846
ISSN1095-9203
AutoresAvinash Patel, Liliana Malinovska, Shambaditya Saha, Jie Wang, Simon Alberti, Yamuna Krishnan, Anthony A. Hyman,
Tópico(s)Endoplasmic Reticulum Stress and Disease
ResumoATP boosts protein solubility Adenosine triphosphate (ATP) has well-characterized roles in providing energy for biochemical reactions within cells. Patel et al. find that ATP may also enhance protein solubility, which could help explain why such high concentrations of ATP are maintained in cells (see the Perspective by Rice and Rosen). Protein concentrations in cells can exceed 100 mg/ml. The authors found that ATP at concentrations found in cells could act as a hydrotrope to help solubilize hydrophobic proteins. The results raise the possibility that ATP concentrations could influence processes such as protein aggregation that occur in disease or liquid-liquid phase separations that occur within cells. Science , this issue p. 753 ; see also p. 701
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