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Energy-sensitive cryogenic detectors for high-mass biomolecule mass spectrometry

1999; Wiley; Volume: 18; Issue: 3-4 Linguagem: Inglês

10.1002/(sici)1098-2787(1999)18

1098-2787

Matthias Frank, Simon E. Labov, Garrett Westmacott, W. Henry Benner,

thermodynamics and calorimetric analyses

Mass Spectrometry ReviewsVolume 18, Issue 3-4 p. 155-186 Review Energy-sensitive cryogenic detectors for high-mass biomolecule mass spectrometry† Matthias Frank, Corresponding Author Matthias Frank Lawrence Livermore National Laboratory, Physics Directorate, V-Division, Livermore, CA 94551Lawrence Livermore National Laboratory, P.O. Box 808, Mail Stop L-418, Livermore, CA 94551Search for more papers by this authorSimon E. Labov, Simon E. Labov Lawrence Livermore National Laboratory, Physics Directorate, V-Division, Livermore, CA 94551Search for more papers by this authorGarrett Westmacott, Garrett Westmacott Lawrence Berkeley National Laboratory, Human Genome Center Instrumentation Group, 1 Cyclotron Rd., Berkeley, CA 94720Search for more papers by this authorW. Henry Benner, W. Henry Benner Lawrence Berkeley National Laboratory, Human Genome Center Instrumentation Group, 1 Cyclotron Rd., Berkeley, CA 94720Search for more papers by this author Matthias Frank, Corresponding Author Matthias Frank Lawrence Livermore National Laboratory, Physics Directorate, V-Division, Livermore, CA 94551Lawrence Livermore National Laboratory, P.O. Box 808, Mail Stop L-418, Livermore, CA 94551Search for more papers by this authorSimon E. Labov, Simon E. Labov Lawrence Livermore National Laboratory, Physics Directorate, V-Division, Livermore, CA 94551Search for more papers by this authorGarrett Westmacott, Garrett Westmacott Lawrence Berkeley National Laboratory, Human Genome Center Instrumentation Group, 1 Cyclotron Rd., Berkeley, CA 94720Search for more papers by this authorW. Henry Benner, W. Henry Benner Lawrence Berkeley National Laboratory, Human Genome Center Instrumentation Group, 1 Cyclotron Rd., Berkeley, CA 94720Search for more papers by this author First published: 28 October 1999 https://doi.org/10.1002/(SICI)1098-2787(1999)18:3/4 3.0.CO;2-WCitations: 69 † This article is a US Government work and, as such, is in the public domain in the United States of America. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Energy-sensitive calorimetric detectors that operate at low temperatures (“cryogenic detectors”) have recently been applied for the first time as ion detectors in time-of-flight mass spectrometry. Compared to conventional, ionization-based detectors, which rely on secondary electron formation or the charge created in a semiconductor, cryogenic detectors measure low-energy solid state excitations created by a particle impact. This energy sensitivity of cryogenic detectors results in several potential advantages for TOF–MS. Cryogenic detectors are expected to have near 100% efficiency even for very large, slow-moving molecules, in contrast to microchannel plates whose efficiency drops considerably at large mass. Thus, cryogenic detectors could contribute to extending the mass range accessible by TOF–MS and help improving detection limits. In addition, the energy resolution provided by cryogenic detectors can be used for charge discrimination and studies of ion fragmentation, ion-detector interaction, and internal energies of large molecular ions. Cryogenic detectors could therefore prove to be a valuable diagnostic tool in TOF–MS. Here, we give a general introduction to the cryogenic detector types most applicable to TOF–MS including those types already used in several TOF–MS experiments. We review and compare the results of these experiments, discuss practical aspects of operating cryogenic detectors in TOF–MS systems, and describe potential near future improvements of cryogenic detectors for applications in mass spectrometry. © 1999 John Wiley & Sons, Inc., Mass Spec Rev 18: 155–186, 1999 References Alessandrello A, Beeman JW, Brofferio C, Cremonesi O, Fiorini E, Giuliani A, Haller EE, Monfardini A, Nucciotti A, Pavan M, Pessina G, Previtali E, Zanotti L. 1999. 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Any queries (other than missing content) should be directed to the corresponding author for the article. Volume18, Issue3-41999Pages 155-186 ReferencesRelatedInformation