Produção Nacional
Revisado por pares
Steatosis caused by experimental periodontitis is reversible after removal of ligature in rats
2017; Wiley; Volume: 52; Issue: 5 Linguagem: Inglês
10.1111/jre.12459
ISSN1600-0765
AutoresJoaquina dos Santos Carvalho, Any Carolina Cardoso Guimarães Vasconcelos, Even Herlany Pereira Alves, André dos Santos Carvalho, Felipe Rodolfo Pereira da Silva, Luíz Felipe de Carvalho França, Antônio de Pádua Rocha Nóbrega Neto, David Di Lenardo, Luan Kelves Miranda de Souza, André Luiz dos Reis Barbosa, Jand Venes Rolim Medeiros, Jefferson Soares de Oliveira, Daniel Fernando Pereira Vasconcelos,
Tópico(s)Alcohol Consumption and Health Effects
ResumoBackground and Objective Periodontitis may promote harmful systemic effects such as changes in hepatic tissues. The purpose of this study was to investigate whether the steatosis and oxidative stress caused by experimental periodontitis are reversible in the liver. Material and Methods Twenty‐four rats were divided into three groups: control, periodontitis and P20‐20 (20 days with experimental periodontitis and 20 days without experimental periodontitis, to verify the reversibility of hepatic injuries). The following parameters were assessed: gingival bleeding index, probing pocket depth, myeloperoxidase activity, alveolar bone loss for periodontal tissues; liver weights, histopathological scores for steatosis, inflammation and necrosis in liver; glutathione, malondialdehyde, total cholesterol and triglyceride concentrations in hepatic tissues; and blood levels of aspartate aminotransferase, alanine aminotransferase, albumin, gamma‐glutaryl transferase, total cholesterol and random glucose. Results Gingival bleeding index , probing pocket depth , myeloperoxidase and alveolar bone loss parameters demonstrated the development of periodontitis. There was a significant reduction in the steatosis score of animals from the P20‐20 group when compared with the periodontitis group. P20‐20 group presented significantly higher glutathione (11 times) and lower malondialdehyde (nearly 23%), total cholesterol (both in blood and hepatic tissue) and triglyceride concentrations compared with the periodontitis group. For levels of aspartate aminotransferase , alanine aminotransferase , albumin, gamma‐glutaryl transferase and random glucose, a significant difference between the groups was not observed. Conclusion Our results demonstrate that the microvesicular steatosis caused by periodontitis in rats is reversible after removal of the ligature, which is associated with the increase in oxidative stress and lipid peroxidation in the liver.
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