Discovery of a widespread metabolic pathway within and among phenolic xenobiotics
2017; National Academy of Sciences; Volume: 114; Issue: 23 Linguagem: Inglês
10.1073/pnas.1700558114
ISSN1091-6490
AutoresPahriya Ashrap, Guomao Zheng, Yi Wan, Tong Li, Wenxin Hu, Wenjuan Li, Hong Zhang, Zhaobin Zhang, Jianying Hu,
Tópico(s)Pesticide and Herbicide Environmental Studies
ResumoSignificance Organisms are exposed to a wide range of xenobiotics in the environment. Generally, metabolism of individual xenobiotics to water-soluble compounds is a primary defense against these compounds. In this study, we discovered that phenolic xenobiotics undergo a metabolic pathway to form lipophilic ester compounds, and the pathway occurred within and among different compounds in organisms. The pathway provided a mechanism for cross-talk reactions among different pollutants to form groups of unknown compounds during metabolic processes in organisms.
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