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Tolerogenic insulin peptide therapy precipitates type 1 diabetes

2017; Rockefeller University Press; Volume: 214; Issue: 7 Linguagem: Inglês

10.1084/jem.20160471

1540-9538

Marie‐Louise Bergman, Thiago Lopes‐Carvalho, Ana C. Martins, Fabio Arturo Grieco, Décio L. Eizirik, Jocelyne Demengeot,

Pancreatic function and diabetes

Daniel et al. (https://doi.org/10.1084/jem.20110574) have previously published in JEM a study on the preventive effect of tolerogenic vaccination with a strong agonist insulin mimetope in type 1 diabetes. Our study now challenges these results and shows that osmotic pump delivery of the modified insulin peptide R22E did not prevent hyperglycemia, accelerated disease onset, increased its incidence, and worsened insulitis.