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Ethanolic Extract of Berberis Vulgaris Fruits Inhibits the Proliferation of MCF-7 Breast Cancer Cell Line Through Induction of Apoptosis

2017; Bentham Science Publishers; Volume: 17; Issue: 3 Linguagem: Inglês

10.2174/1871526517666170531113759

2212-3989

Ehsan Ghafourian, Nourkhoda Sadeghifard, Iraj Pakzad, Nasrin Valizadeh, Abbas Maleki, Fataneh Jafari, Nastaran Ghiasvand, Jahangir Abdi, Yalda Shokoohinia, Sobhan Ghafourian,

Berberine and alkaloids research

Background: As it is obvious, there is much documentation that shows the importance of breast cancer treatment in patients. High expressions of P53 and Bcl-2 are associated with breast cancer, which are reliable factors to follow up the breast cancer. Berberis vulgaris is used as a traditional medicine in cancer. Despite of the fact that many researches have demonstrated its anti-cancer properties, there are no scientific documents to show its efficacy in detail in breast cancer. Keywords: Berberis vulgaris, breast neoplasms, Bcl-2, crude extract, MCF-7, p53.