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Microglia-glioblastoma interactions: New role for Wnt signaling

2017; Elsevier BV; Volume: 1868; Issue: 1 Linguagem: Inglês

10.1016/j.bbcan.2017.05.007

1879-2561

Diana Matias, Danilo Predes, Paulo Niemeyer Filho, María Celeste Lopes, José G. Abreu, Flávia Regina Souza Lima, Vivaldo Moura‐Neto,

MicroRNA in disease regulation

Glioblastoma, the most aggressive and fatal type of brain tumor, is capable of interacting with brain immune cells such as microglia, which contributes to the growth of these tumors. Various molecules, including growth factors and cytokines, have been identified as regulators of microglia-glioblastoma interaction. Recent studies suggest that the Wnt family of lipoglycoproteins plays an important role, not only in biological events during development, but also in cancer progression, and can be part of microglia recruitment to glioblastoma as well as of tumor growth and invasion. Here, we discuss recent interesting findings that support a role for Wnt signaling pathways in the microglia-glioblastoma crosstalk.