
Cancer Related Fatigue and Muscle Quality in Hodgkin’s Lymphoma Survivors
2017; Lippincott Williams & Wilkins; Volume: 49; Issue: 5S Linguagem: Inglês
10.1249/01.mss.0000518784.24508.ac
ISSN1530-0315
AutoresFilipe Dinato de Lima, Cláudio L. Battaglini, Ricardo Jacó de Oliveira, Ritielli de Oliveira Valeriano, Lorena Fernández de la Cruz, Carlos Alexandre Vieira, Martim Bottaro,
Tópico(s)Nutrition and Health in Aging
ResumoCancer-related fatigue is the most commonly reported side effect in cancer patients. This debilitating fatigue is often accompanied by reductions in overall physical activity and physical function. Whereas fatigue in cancer survivors seems partially dependent on neuromuscular factors, these relationships have not been established in Hodgkin's lymphoma survivors (HLS). PURPOSE: To assess self-perceived fatigue and muscle quality in Hodgkin's Lymphoma survivors. METHODS: A total of 12 HLS, age 32.16 ± 8.06, and 36 control healthy subjects (CON) matched by age, gender and level of physical activity were enrolled in the study. Fatigue was measured using MFI-20. Muscle thickness of knee extensors (MT) was measured using B-mode ultrasound. Muscle quality was assessed by echo intensity (EI) of rectus femoris and specific torque (ST) of the knee extensors. The ST was calculated as follows: isokinetic peak torque (PT)/MT. Isokinetic PT was measured by two sets of four maximal isokinetic knee extension at 60°/s-1. Independent samples T-tests were used to compare physical characteristics, muscle function and fatigue between HLS and CON. RESULTS: No significant differences (p > 0.05) in any physical characteristics between HLS and CON were observed. There was no difference in PT (HLS: 184.58 ± 55.91 vs. CON: 199.14 ± 60.57 N.m; p = 0.552), MT (HLS: 27.35 ± 8.70 vs. CON: 28.55 ± 7.58 mm; p = 0.439), EI (HLS: 63.18 ± 11.12 vs. CON: 65.36 ± 11.76; p = 0.575), and ST (HLS: 6.89 ± 1.59 vs. CON: 7.05 ± 1.46 N.m.mm-1; p = 0.737). However, there was a significant difference between HLS and CON for self-perceived fatigue (HLS: 14.00 ± 3.91 vs. CON: 10.80 ± 3.36; p = 0.009; ES = 0.8778). CONCLUSION: A higher level of self-perceived fatigue was observed in HLS when compared to CON. However, no differences in muscle quality were observed when HLS are matched by age, gender and physical activity level with CON. It appears that as HLS are further out from the completion of their major treatments, their muscle characteristics and function are preserved if they maintain certain level of physical activity. This study provides insight on the potential similarities between HLS and CON, with same physical activities level, regarding muscle characteristics, function, and performance, which should be considered when prescribing exercise training to this population.
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