Synthesis, characterization, and application of a novel water-soluble polyethyleneimine-based Schiff base colorimetric chemosensor for metal cations and biological activity
2017; Elsevier BV; Volume: 252; Linguagem: Inglês
10.1016/j.snb.2017.05.159
ISSN1873-3077
AutoresMustafa Yıldız, Neslihan Demir, Hüseyin Ünver, Nurettin Şahiner,
Tópico(s)Antimicrobial agents and applications
ResumoA novel colorimetric cation sensor based on polyethyleneiminehydrochloride (PEI.HCl) as Schiff base was synthesized. The molecular structure of the PEI.HCl-Schiff base was characterized via FT-IR, 1H NMR, 13C NMR, LC-MS and UV–vis spectroscopic methods The chromogenic sensing ability of PEI.HCl-Schiff base was investigated with colorimetric and UV–vis spectroscopy. The designed sensor exhibited highly selective recognition for Fe2+, Co2+, Cu2+, Cr3+, and Fe3+ amongst a wide range of metal ions tested in water. In the presence of these cations, the sensor underwent a dramatic colour change from yellow to green, while the presence of other metal cations such as Mn2+, Ni2+, Zn2+, Cd2+, Hg2+ and Pb2+ produced no effect on the colour. The absorption spectral changes were observed upon the addition of Fe2+, Co2+, Cu2+, Cr3+, and Fe3+ with impressive naked eye detectable colour change from yellow to dark-gray, light-brown, green, light-green and brown, respectively. The most discernable colour change in the PEI.HCl-Schiff base was caused by Fe2+, Co2+, Cu2+, Cr3+, and Fe3+ suggesting the selective detection of these metal cations. Surprisingly, PEI.HCl-Schiff base behaves as highly selective chemical sensor for the oxidation of Fe2+ to Fe3+ cations. Moreover, the antimicrobial activity of PEI.HCl-Schiff base was tested for its minimum inhibitory concentration (MIC), and the interaction with calf thymus DNA (CT-DNA) was investigated using UV–vis spectroscopy. DNA cleavage study showed that PEI.HCl-Schiff base can successfully cleave DNA without any external agents.
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