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Artigo Revisado por pares
BIBTEX RIS

Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s

2017; Elsevier BV; Volume: 124; Issue: 3 Linguagem: Inglês

10.1016/j.radonc.2017.05.003

ISSN

1879-0887

Autores

Pierre Montay‐Gruel, Kristoffer Petersson, Maud Jaccard, Gaël Boivin, Jean‐François Germond, Benoît Petit, Raphaël Doenlen, Vincent Favaudon, François Bochud, Claude Bailat, Jean Bourhis, Marie‐Catherine Vozenin,

Tópico(s)

Radiation Therapy and Dosimetry

Resumo

This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate. Spatial memory is preserved after WBI with mean dose rates above 100Gy/s, whereas 10Gy WBI at a conventional radiotherapy dose rate (0.1Gy/s) totally impairs spatial memory.

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