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Biotin Interference with Routine Clinical Immunoassays: Understand the Causes and Mitigate the Risks

2017; Elsevier BV; Volume: 23; Issue: 8 Linguagem: Inglês

10.4158/ep171761.ra

1934-2403

Shanika Samarasinghe, Farah Meah, Vinita Singh, Arshi Basit, Nicholas Emanuele, Mary Ann Emanuele, Alaleh Mazhari, E W Holmes,

Click Chemistry and Applications

Objective: The objectives of this report are to review the mechanisms of biotin interference with streptavidin/biotin-based immunoassays, identify automated immunoassay systems vulnerable to biotin interference, describe how to estimate and minimize the risk of biotin interference in vulnerable assays, and review the literature pertaining to biotin interference in endocrine function tests.