The t(15;17) translocation alters a nuclear body in a retinoic acid-reversible fashion.
1994; Springer Nature; Volume: 13; Issue: 5 Linguagem: Inglês
10.1002/j.1460-2075.1994.tb06356.x
ISSN1460-2075
AutoresMarcel Koken, F Puvion-Dutilleul, Marie-Claude Guillemin, A Viron, Gustavo Linares‐Cruz, Nico Stuurman, Luitzen de Jong, Carin Szostecki, Fabien Calvo, Christine Chomienne,
Tópico(s)Cancer-related Molecular Pathways
ResumoResearch Article1 March 1994free access The t(15;17) translocation alters a nuclear body in a retinoic acid-reversible fashion. M.H. Koken M.H. Koken CNRS UPR 43, Centre Hayem, Hôpital St Louis, Paris, France. Search for more papers by this author F. Puvion-Dutilleul F. Puvion-Dutilleul CNRS UPR 43, Centre Hayem, Hôpital St Louis, Paris, France. Search for more papers by this author M.C. Guillemin M.C. Guillemin CNRS UPR 43, Centre Hayem, Hôpital St Louis, Paris, France. Search for more papers by this author A. Viron A. Viron CNRS UPR 43, Centre Hayem, Hôpital St Louis, Paris, France. Search for more papers by this author G. Linares-Cruz G. Linares-Cruz CNRS UPR 43, Centre Hayem, Hôpital St Louis, Paris, France. Search for more papers by this author N. Stuurman N. Stuurman CNRS UPR 43, Centre Hayem, Hôpital St Louis, Paris, France. Search for more papers by this author L. de Jong L. de Jong CNRS UPR 43, Centre Hayem, Hôpital St Louis, Paris, France. Search for more papers by this author C. Szostecki C. Szostecki CNRS UPR 43, Centre Hayem, Hôpital St Louis, Paris, France. Search for more papers by this author F. Calvo F. Calvo CNRS UPR 43, Centre Hayem, Hôpital St Louis, Paris, France. Search for more papers by this author C. Chomienne C. Chomienne CNRS UPR 43, Centre Hayem, Hôpital St Louis, Paris, France. Search for more papers by this author M.H. Koken M.H. Koken CNRS UPR 43, Centre Hayem, Hôpital St Louis, Paris, France. Search for more papers by this author F. Puvion-Dutilleul F. Puvion-Dutilleul CNRS UPR 43, Centre Hayem, Hôpital St Louis, Paris, France. Search for more papers by this author M.C. Guillemin M.C. Guillemin CNRS UPR 43, Centre Hayem, Hôpital St Louis, Paris, France. Search for more papers by this author A. Viron A. Viron CNRS UPR 43, Centre Hayem, Hôpital St Louis, Paris, France. Search for more papers by this author G. Linares-Cruz G. Linares-Cruz CNRS UPR 43, Centre Hayem, Hôpital St Louis, Paris, France. Search for more papers by this author N. Stuurman N. Stuurman CNRS UPR 43, Centre Hayem, Hôpital St Louis, Paris, France. Search for more papers by this author L. de Jong L. de Jong CNRS UPR 43, Centre Hayem, Hôpital St Louis, Paris, France. Search for more papers by this author C. Szostecki C. Szostecki CNRS UPR 43, Centre Hayem, Hôpital St Louis, Paris, France. Search for more papers by this author F. Calvo F. Calvo CNRS UPR 43, Centre Hayem, Hôpital St Louis, Paris, France. Search for more papers by this author C. Chomienne C. Chomienne CNRS UPR 43, Centre Hayem, Hôpital St Louis, Paris, France. Search for more papers by this author Author Information M.H. Koken1, F. Puvion-Dutilleul1, M.C. Guillemin1, A. Viron1, G. Linares-Cruz1, N. Stuurman1, L. Jong1, C. Szostecki1, F. Calvo1 and C. Chomienne1 1CNRS UPR 43, Centre Hayem, Hôpital St Louis, Paris, France. The EMBO Journal (1994)13:1073-1083https://doi.org/10.1002/j.1460-2075.1994.tb06356.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Nuclear bodies (NBs) are ultrastructurally defined granules predominantly found in dividing cells. Here we show that PML, a protein involved in the t(15;17) translocation of acute promyelocytic leukaemia (APL), is specifically bound to a NB. PML and several NB-associated proteins, found as auto-antigens in primary biliary cirrhosis (PBC), are co-localized and co-regulated. The APL-derived PML-RAR alpha fusion protein is shown to be predominantly localized in the cytoplasm, whereas a fraction is nuclear and delocalizes the NB antigens to multiple smaller nuclear clusters devoid of ultrastructural organization. RA administration (which in APL patients induces blast differentiation and consequently complete remissions) causes the re-aggregation of PML and PBC auto-antigens onto the NB, while PML-RAR alpha remains mainly cytoplasmic. Thus, PML-RAR alpha expression leads to a RA-reversible alteration of a nuclear domain. These results shed a new light on the pathogenesis of APL and provide a molecular link between NBs and oncogenesis. Previous ArticleNext Article Volume 13Issue 51 March 1994In this issue RelatedDetailsLoading ...
Referência(s)