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Effect of D-ribose-L-cysteine on aluminum induced testicular damage in male Sprague-Dawley rats

2017; Brazilian Society of Assisted Reproduction; Volume: 21; Issue: 2 Linguagem: Inglês

10.5935/1518-0557.20170023

1518-0557

B.A. Falana, Opeyemi Adeleke, Mulikat Orenolu, A.A. Osinubi, Adeoye Oyetunji Oyewopo,

Carcinogens and Genotoxicity Assessment

This study investigated the effects of D-ribose and L-cysteine on aluminum-induced testicular damage in male Sprague-Dawley rats.A total number of thirty-five (35) adult male Sprague-Dawley rats were divided into four groups (AD). Group A (comprised five (5) rats) was designated the Control Group that received Physiological Saline; while groups B, C, and D (comprised ten (10) rats) were given 75 mg/kg, 150 mg/kg and 300 mg/kg of body weight of aluminum chloride respectively for 39 days. At day 40, the aluminum-treated groups were subdivided into sub-groups (B1, C1, D1) comprising of five (5) rats each, and 30 mg/kg body weight of Riboceine were administered for twenty (20) days. Groups B, C and D remained on the normal dosage of aluminum chloride for three more weeks (59 days).Andrological parameters (Sperm count, motility, morphology and testosterone) in the aluminum-treated Groups B and C showed no significant difference in their mean values when compared with their control counterparts, whereas there was a significant reduction in the andrological parameters in Group D rats when compared with the Control animals. Histoarchitecture of the testes "stain with H&E" of Group A, B and C rats appeared normal while Group D rats showed testicular damages with several abnormal seminiferous tubules with incomplete maturation of germinal cell layers and absence of spermatozoa in their lumen; Leydig cells appear hyperplastic. Group B1, C1 and D1 andrological and histological parameters appeared normal.Riboceine treatment significantly attenuates aluminum-induced testicular toxicity in male Sprague-Dawley in rats.