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Microvesicles in vascular homeostasis and diseases

2017; Thieme Medical Publishers (Germany); Volume: 117; Issue: 07 Linguagem: Inglês

10.1160/th16-12-0943

2567-689X

Victoria Ridger, Chantal M. Boulanger, Anne Angelillo‐Scherrer, Lina Badimón, Olivier Blanc‐Brude, Marie‐Luce Bochaton‐Piallat, Éric Boilard, Edit I. Buzás, Andreas Caporali, Françoise Dignat‐George, Paul C. Evans, Romaric Lacroix, Esther Lutgens, Daniel F.J. Ketelhuth, Rienk Nieuwland, Florence Toti, José Tuñón, Christian Weber, Imo E. Hoefer, Gregory Y.H. Lip, Nikos Werner, Eduard Shantsila, Hugo Ten Cate, Mark Thomas, Paul Harrison,

Viral Infections and Vectors

Summary Microvesicles are members of the family of extracellular vesicles shed from the plasma membrane of activated or apoptotic cells. Microvesicles were initially characterised by their pro-coagulant activity and described as “microparticles”. There is mounting evidence revealing a role for microvesicles in intercellular communication, with particular relevance to hemostasis and vascular biology. Coupled with this, the potential of microvesicles as meaningful biomarkers is under intense investigation. This Position Paper will summarise the current knowledge on the mechanisms of formation and composition of microvesicles of endothelial, platelet, red blood cell and leukocyte origin. This paper will also review and discuss the different methods used for their analysis and quantification, will underline the potential biological roles of these vesicles with respect to vascular homeostasis and thrombosis and define important themes for future research.