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Artigo Produção Nacional Revisado por pares
BIBTEX RIS

Biomarker release after percutaneous coronary intervention in patients without established myocardial infarction as assessed by cardiac magnetic resonance with late gadolinium enhancement

2017; Wiley; Volume: 90; Issue: 1 Linguagem: Inglês

10.1002/ccd.27125

ISSN

1522-726X

Autores

Rodrigo Morel Vieira de Melo, Whady Hueb, César Higa Nomura, Expedito E. Ribeiro, Alexandre Volney Villa, Fernando Teiichi Costa Oikawa, Leandro Menezes Alves da Costa, Paulo Cury Rezende, Cibele Larrosa Garzillo, Eduardo Gomes Lima, José Antônio Franchini Ramires, Roberto Kalil Filho,

Tópico(s)

Coronary Interventions and Diagnostics

Resumo

This study aimed to evaluate the amount and pattern of cardiac biomarker release after elective percutaneous coronary intervention (PCI) in patients without evidence of a new myocardial infarction (MI) after the procedure as assessed by cardiac magnetic resonance (CMR) with late gadolinium enhancement (LGE).The release of myocardial necrosis biomarkers after PCI frequently occurs. However, the correlation between biomarker release and the diagnosis of procedure-related MI type 4a has been controversial.Patients with normal baseline cardiac biomarkers who were referred for elective PCI were prospectively included. CMR with LGE was performed in all of the patients before and after the intervention. Measurements of troponin I (TnI) and creatine kinase MB fraction (CK-MB) were systematically performed before and after the procedure. Patients with a new LGE on the post-procedure CMR were excluded.Of the 56 patients with no evidence of a procedure-related MI as assessed by CMR after the PCI, 48 (85.1%) exhibited an elevation of TnI above the 99th percentile. In 32 patients (57.1%), the peak was greater than five times this limit. Additionally, 17 patients (30.4%) had a CK-MB peak above the 99th percentile limit, but this peak was greater than five times the 99th percentile in only two patients (3.6%). The median peak release of TnI was 0.290 (0.061-1.09) ng/mL, which was 7.25-fold higher than the 99th percentile.In contrast to CK-MB, an abnormal release of TnI often occurs after an elective PCI procedure, despite the absence of a new LGE on CMR.

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