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Protein malnutrition blunts the increment of taurine transporter expression by a high‐fat diet and impairs taurine reestablishment of insulin secretion

2017; Wiley; Volume: 31; Issue: 9 Linguagem: Inglês

10.1096/fj.201600326rrr

1530-6860

Renato Chaves Souto Branco, Rafael Ludemann Camargo, Thiago M. Batista, Jean Franciesco Vettorazzi, Patrícia Cristine Borck, Junia Carolina Rebelo Santos‐Silva, Antônio C. Boschero, Cláudio C. Zoppi, Everardo M. Carneiro,

Pancreatic function and diabetes

Taurine (Tau) restores β-cell function in obesity; however, its action is lost in malnourished obese rodents. Here, we investigated the mechanisms involved in the lack of effects of Tau in this model. C57BL/6 mice were fed a control diet (CD) (14% protein) or a protein-restricted diet (RD) (6% protein) for 6 wk. Afterward, mice received a high-fat diet (HFD) for 8 wk [CD + HFD (CH) and RD + HFD (RH)] with or without 5% Tau supplementation after weaning on their drinking water [CH + Tau (CHT) and RH + Tau (RHT)]. The HFD increased insulin secretion through mitochondrial metabolism in CH and RH. Tau prevented all those alterations in CHT only. The expression of the taurine transporter (Tau-T), as well as Tau content in pancreatic islets, was increased in CH but had no effect on RH. Protein malnutrition programs β cells and impairs Tau-induced restoration of mitochondrial metabolism and biogenesis. This may be associated with modulation of the expression of Tau-T in pancreatic islets, which may be responsible for the absence of effect of Tau in protein-malnourished obese mice.-Branco, R. C. S., Camargo, R. L., Batista, T. M., Vettorazzi, J. F., Borck, P. C., dos Santos-Silva, J. C. R., Boschero, A. C., Zoppi, C. C., Carneiro, E. M. Protein malnutrition blunts the increment of taurine transporter expression by a high-fat diet and impairs taurine reestablishment of insulin secretion.