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Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

2017; Cell Press; Volume: 169; Issue: 6 Linguagem: Inglês

10.1016/j.cell.2017.05.016

1097-4172

Roel Nusse, Hans Clevers,

Epigenetics and DNA Methylation

The WNT signal transduction cascade is a main regulator of development throughout the animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult mammals. Unsurprisingly, mutated Wnt pathway components are causative to multiple growth-related pathologies and to cancer. Here, we describe the core Wnt/β-catenin signaling pathway, how it controls stem cells, and contributes to disease. Finally, we discuss strategies for Wnt-based therapies.