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The effect of thiol content on the gelation and mucoadhesion of thiolated poly(aspartic acid)

2017; Wiley; Volume: 66; Issue: 11 Linguagem: Inglês

10.1002/pi.5411

1097-0126

Barnabás Áron Szilágyi, Benjámin Gyarmati, Gabriella Horvát, Ádám Laki, Mária Budai-Szűcs, Erzsébet Csányi, Giuseppina Sandri, Maria Cristina Bonferoni, András Szilágyi,

Hydrogels: synthesis, properties, applications

Polymer InternationalVolume 66, Issue 11 p. 1538-1545 Research Article The effect of thiol content on the gelation and mucoadhesion of thiolated poly(aspartic acid) Barnabás Áron Szilágyi, Barnabás Áron Szilágyi Soft Matters Group, Department of Physical Chemistry and Materials Science, Budapest University of Technology and Economics, Budapest, HungarySearch for more papers by this authorBenjámin Gyarmati, Benjámin Gyarmati orcid.org/0000-0002-8795-7264 Soft Matters Group, Department of Physical Chemistry and Materials Science, Budapest University of Technology and Economics, Budapest, HungarySearch for more papers by this authorGabriella Horvát, Gabriella Horvát Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Szeged, HungarySearch for more papers by this authorÁdám Laki, Ádám Laki Soft Matters Group, Department of Physical Chemistry and Materials Science, Budapest University of Technology and Economics, Budapest, HungarySearch for more papers by this authorMária Budai-Szűcs, Mária Budai-Szűcs orcid.org/0000-0001-5187-5702 Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Szeged, HungarySearch for more papers by this authorErzsébet Csányi, Erzsébet Csányi Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Szeged, HungarySearch for more papers by this authorGiuseppina Sandri, Giuseppina Sandri orcid.org/0000-0001-6766-9321 Department of Drug Sciences, University of Pavia, Pavia, ItalySearch for more papers by this authorMaria Cristina Bonferoni, Maria Cristina Bonferoni orcid.org/0000-0002-1194-9372 Department of Drug Sciences, University of Pavia, Pavia, ItalySearch for more papers by this authorAndrás Szilágyi, Corresponding Author András Szilágyi aszilagyi@mail.bme.hu orcid.org/0000-0001-6898-1755 Soft Matters Group, Department of Physical Chemistry and Materials Science, Budapest University of Technology and Economics, Budapest, HungaryCorrespondence to: A Szilágyi, Soft Matters Group, Department of Physical Chemistry and Materials Science, Budapest University of Technology and Economics, Budapest, Hungary. E-mail: aszilagyi@mail.bme.huSearch for more papers by this author Barnabás Áron Szilágyi, Barnabás Áron Szilágyi Soft Matters Group, Department of Physical Chemistry and Materials Science, Budapest University of Technology and Economics, Budapest, HungarySearch for more papers by this authorBenjámin Gyarmati, Benjámin Gyarmati orcid.org/0000-0002-8795-7264 Soft Matters Group, Department of Physical Chemistry and Materials Science, Budapest University of Technology and Economics, Budapest, HungarySearch for more papers by this authorGabriella Horvát, Gabriella Horvát Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Szeged, HungarySearch for more papers by this authorÁdám Laki, Ádám Laki Soft Matters Group, Department of Physical Chemistry and Materials Science, Budapest University of Technology and Economics, Budapest, HungarySearch for more papers by this authorMária Budai-Szűcs, Mária Budai-Szűcs orcid.org/0000-0001-5187-5702 Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Szeged, HungarySearch for more papers by this authorErzsébet Csányi, Erzsébet Csányi Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Szeged, HungarySearch for more papers by this authorGiuseppina Sandri, Giuseppina Sandri orcid.org/0000-0001-6766-9321 Department of Drug Sciences, University of Pavia, Pavia, ItalySearch for more papers by this authorMaria Cristina Bonferoni, Maria Cristina Bonferoni orcid.org/0000-0002-1194-9372 Department of Drug Sciences, University of Pavia, Pavia, ItalySearch for more papers by this authorAndrás Szilágyi, Corresponding Author András Szilágyi aszilagyi@mail.bme.hu orcid.org/0000-0001-6898-1755 Soft Matters Group, Department of Physical Chemistry and Materials Science, Budapest University of Technology and Economics, Budapest, HungaryCorrespondence to: A Szilágyi, Soft Matters Group, Department of Physical Chemistry and Materials Science, Budapest University of Technology and Economics, Budapest, Hungary. E-mail: aszilagyi@mail.bme.huSearch for more papers by this author First published: 10 June 2017 https://doi.org/10.1002/pi.5411Citations: 19Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract A synthetic poly(amino acid), poly(aspartic acid) modified with thioethyl side groups, was studied as an in situ gelling and mucoadhesive dosage form. The chemical structure and the controllable, large thiol content of the polymer were confirmed using 1H NMR spectroscopy and Ellman's assay. In situ gelation of aqueous polymer solutions was induced by oxidation and monitored using oscillation rheometry. The strength of mucoadhesion towards excised mucosa was characterised by tensile tests in ex vivo experiments. Release kinetics of ophthalmic antibiotic ofloxacin was studied from an in situ crosslinked hydrogel and a liquid formulation to prove the sustained release of the former. © 2017 Society of Chemical Industry Citing Literature Supporting Information Filename Description pi5411-sup-0001-AppendixS1.pdfWord 2007 document , 132.7 KB Appendix S1. Figure S1. 1H-1H COSY NMR (500 MHz, D2O) spectrum of oxidised PASP-CEA5 Figure S2. First 4 hours of ofloxacin release from thiolated poly(aspartic acid) hydrogels (cpolymer = 10 wt%, in pH = 7.4 PBS, T = 35 °C). Results are mean of 3 experiments Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume66, Issue11November 2017Pages 1538-1545 RelatedInformation