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The Reactivity of 4’-Substituted Spiro[Isoindole-1,3’-pyrazoles] Derivatives: Substitution/Elimination Reactions and Access to Biaryl Derivatives

2017; Elsevier BV; Volume: 94; Issue: 2 Linguagem: Inglês

10.3987/com-16-13543

1881-0942

Giuseppe Daidone, Benedetta Maggio, Gianfranco Fontana, Maria Valeria Raimondi, Demetrio Raffa, Fabiana Plescia, Angela Maria Ingarra,

Synthesis and pharmacology of benzodiazepine derivatives

This paper describes aspects of the chemistry of 4'-substituted spiro[isoindole-1,3'-pyrazoles].These compounds underwent substitution and/or elimination reactions to afford some new spiro-as well as biaryl derivatives of potential pharmaceutical relevance.Mechanistic considerations are discussed as well.