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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

First serological evidence of hantavirus among febrile patients in Mozambique

2017; Elsevier BV; Volume: 61; Linguagem: Inglês

10.1016/j.ijid.2017.06.001

ISSN

1878-3511

Autores

Ramalho Maximiano Chau, Nilesh Bhatt, Ivan Manhiça, Sandra Cândido, Nilsa de Deus, Onélia Guiliche, Almiro Tivane, Lara Virgínia Evaristo, Alexandro Guterres, Vanessa Monteiro, Jorlan Fernandes, Renata Carvalho de Oliveira, Elba Regina Sampaio de Lemos, Eduardo Samo Gudo,

Tópico(s)

Viral Infections and Outbreaks Research

Resumo

ObjectiveThe occurrence of hantavirus in Sub-Saharan Africa is poorly studied and its clinical implications are unknown. This study aimed to determine the occurrence of hantavirus infection among febrile patients attending an outpatient clinic at a primary health care center located in a suburban area of the city of Maputo in Mozambique.MethodsPaired acute and convalescent samples from a total of 200 febrile patients aged >5 years who were recruited between February 2012 and October 2014 were screened for IgM and IgG antibodies against hantavirus using an ELISA. Acute samples were also screened for malaria and to determine hematological and clinical chemistry parameters.ResultsOf the 200 patients enrolled, four had IgM antibodies in their acute sample and IgG antibodies in their convalescent sample, yielding a prevalence rate of 2%.Contact with rodents was higher among IgM-positive participants than IgM-negative participants (50.0% (2/4) vs. 15.3% (30/196)). IgM-positive patients presented significantly higher levels of creatinine and alanine aminotransferase and lower platelet counts than IgM-negative patients.ConclusionsThe findings of this study demonstrate human exposure to hantavirus in Mozambique for the first time; however, further studies should be conducted to investigate its clinical implications.

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