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Role of Immune Cells in Acute Kidney Injury and Repair

2017; Volume: 137; Issue: 4 Linguagem: Inglês

10.1159/000477181

2235-3186

Sul A Lee, Sanjeev Noel, Mohanraj Sadasivam, Abdel R.A. Hamad, Hamid Rabb,

Dialysis and Renal Disease Management

Acute kidney injury (AKI) is a significant problem in both native and transplant kidneys. There have been significant advances in understanding the role of immune cells in the early injury and repair from AKI. In this brief review, we aim to update information on the pathophysiologic impact of various immune cells in AKI, with special emphasis on repair. An improved understanding of the AKI immunopathology will lead to new therapies that prevent AKI, accelerate repair, and prevent the progression of AKI to chronic kidney disease.